Compare and contrast the physiological properties of electrical and chemical synapses.Predict the effects of demyelination on the conduction properties of axons. Categorize nerve fibres based on conduction velocity and develop a functional definition of the length constant. Outline the molecular mechanism that results in saltatory and unidirectional conduction of an action potential along an axon.Define the absolute and relative refractory periods, and be able to explain the molecular basis for these periods. Understand the implications of the "all-or-none" principle. Compare and contrast graded and action potentials, particularly with respect to polarization, magnitude, propagation and ion channels responsible for each type of membrane potential change.Diagram an action potential, and define the ionic basis of each stage of an AP.This lab will reinforce the concepts presented on this website and in "lecture" by demonstrating the application of fundamental principles of membrane potentials to the clinical problem of multiple sclerosis.Īt the end of the "lecture" and lab sessions, you should be able to: It is assumed that students will have reviewed the material on this website, or will have read the relevant sections in any Physiology textbook - or in the Medical Neurobiology textbook (required for the Neurological Medicine course). These sessions will be used to clarify and demonstrate fundamental principles using quizzes and demonstrations, rather than lecturing. "Lectures" on Graded/Action Potentials and Neurotransmission (synaptic communication). The neural communication module consists of 2 distinct parts:
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